The backpressure required by standard chromatography column packings is a major drawback impacting operational and financial costs. Some attempts have been made to address this issue by taking advantage of an array of parallel channels. However, the dimensions polydispersity between the capillaries makes the solution unpractical. Even if the polydispersity is low, the column efficiency decreases drastically .
Using numerical simulations, we have shown that the superimposition of a radial diffusive term between adjacent channels removes this limitation. The behaviour becomes similar to a common chromatography packing with a pressure drop of one order of magnitude lower compared to equivalent columns [2, 3].
We have introduced an experimental proof of this theoretical model using silica monolithic and multicapillary columns. manufacturing The columns are made from a bundle of fibres embedded in a silica porous matrix. These columns allow the separation of compounds with a similar efficiency as classical packed columns but showing for the same flow rate, a far below pressure drop.
Our expertise allows us to tune many parameters as the number of capillary and their dimensions to control resolution, time analysis, loading capacity and solvent consumption.
This new technology offers unique performances. For analytical chromatography, the increase of efficiency and time saving are the main advantages. For preparative chromatography, we consider that separations could be made at low pressure, keeping the same efficiency at considerably lower operating costs.
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|||F. Parmentier, «Effect of diffusional bridging in multicapillary packing,» Comptes Rendus de la Chimie, pp. 415-431, 2020.|
|||F. Gritti, D. Hlushkou et U. Tallarek, «Multiple-open-tubular column enabling transverse diffusion. Part 2: Channel size distribution and structure optimization,» Journal of Chromatography A, 2021.|