Pressure drop in a chromatography column is a measure of the resistance of the column to the flow of the mobile phase.
 

Separative columns are designed with a set of parallel channels, similar to a honeycomb structure. This innovative design reduces the pressure drop across the column, allowing for low-pressure separation.
 

In traditional packed bed columns, the flow of the mobile phase is governed by Darcy's law. However, in Separative's multicapillary monolithic columns, the flow is governed by Poiseuille's law. This results in a significant reduction in pressure drop, without sacrificing separation efficiency.